Name: K02288
Price: 305.00 USD

- Overview
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    Background
    
    K02288 is a highly selective inhibitor of ALK2 with IC50 value of 1.1nM [1].K02288 is a 2-aminopyridine inhibitor of ALK2. It shows high selectivity for the homologous kinases ALK1-6 and ActRIIA. K02288 shows potency against the type I BMP receptors ALK1, ALK2 (IC50s range from 1–2nM), ALK3 and ALK6 (IC50s of 5–34nM), ALK4 (IC50 of 302nM) and ALK5 (IC50 of 321nM). K02288 has a favorable kinome-wide selectivity. In a panel of 200 human kinases, it shows more than 50% inhibition against only ABL and ARG at 0.1μM and only a further 6 kinases at 1μM [1]. K02288 also affects ALK2 related BMP signaling. In C2C12 cells, it reduces the phosphorylation of Smad dose-dependently when using BMP4 or BMP6 as ligands. Furthermore, K02288 induces a dorsalized phenotype in Tg(BRE:mRFP) transgenic zebrafish embryos [1].
    
    [1] Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721.
- Properties
  - Alternative Name
    
    3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol
    
    CAS Number
    
    1431985-92-0
    
    Molecular Formula
    
    C20H20N2O4
    
    Molecular Weight
    
    352.38
    
    Appearance
    
    A solid
    
    Purity
    
    99.91%
    
    Solubility
    
    insoluble in H2O; ≥17.6 mg/mL in DMSO; ≥2.5 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

K02288

K02288

Background

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