Name: JW 55
Price: 244.00 USD

- Overview
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    Background
    
    IC50: 1.9 μM (TNK S1); 0.83 μM (TNK S2) Increased nuclear accumulation of β-catenin, a mediator of canonical Wnt signaling, is found in numerous tumors and is frequently associated with tumor progression and metastasis. Inhibition of Wnt/b-catenin signaling therefore is an attractive strategy for anticancer drugs. In vitro: In a previous study, the authors identified a novel small molecule inhibitor of the β-catenin signaling pathway, JW55, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the b-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 led to stabilization of AXIN2, a member of the b-catenin destruction complex, followed by increased degradation of b-catenin. In a dose-dependent manner, JW55 inhibited canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of b-catenin [1]. In vivo: JW55 was reported to reduce XWnt8-induced axis duplication in Xenopus embryos and tamoxifen-induced polyposis formation in conditional APC mutant mice. These findings provide a novel chemotype for targeting canonical Wnt/b-catenin signaling through inhibiting the PARP domain of TNKS1/2 [1]. Clinical trial: JW55 is currently in the preclinical development and no clinical trial is ongoing.
- Properties
  - Alternative Name
    
    N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
    
    CAS Number
    
    664993-53-7
    
    Molecular Formula
    
    C25H26N2O5
    
    Molecular Weight
    
    434.48
    
    Appearance
    
    A solid
    
    Purity
    
    99.31%
    
    Solubility
    
    insoluble in H2O; ≥19.25 mg/mL in DMSO; ≥3.53 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at 4°C
    
    * For Research Use Only

JW 55

JW 55

Background

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