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Overview
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Background
IRAK inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].IRAK-4 belongs to Interleukin-1 Receptor-Associated Kinase, which are key components in the signal transduction pathways. IRAK-4 is an essential signal transducer downstream of interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R) and Toll-like receptors (TLRs). Inhibition of IRAK-4 can modulate its function, thus toning down inflammatory responses. IRAK inhibitor 4 is an indazole inhibitor. As inhibitors of IRAK-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].
[1] Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh. IRAK-4 Inhibitors for Inflammation. Current Topics in Medicinal Chemistry. 2009, 9: 724-737.
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