Intact Proinsulin ELISA

Proinsulin is a precursor molecule for insulin and is synthesized by the pancreatic β-cells. Under normal circumstances, virtually all proinsulin is cleaved at residues 32-33 and 65-66 to produce insulin during the formation of secretory granules. Some unmodified proinsulin is released into the circulation, though it is believed to have little or no biological activity. Increased concentrations of circulating proinsulin may occur in insulin-resistant syndromes such as type 2 diabetes and in patients with insulinoma. When used in conjunction with a highly specific insulin assay, it may provide useful information on changes in the processing of insulin in such situations.

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