INCB 3284 dimesylate

INCB 3284 dimesylate

Catalog Number:
L002368684APE
Mfr. No.:
APE-A3492
Price:
$405
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      • Overview
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          Background

          INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist. INCB 3284 exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). INCB 3284 also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM).

      • Properties
        • Categories
          HCCR2 antagonist
          Alternative Name
          INCB-3284 dimesylate;INCB3284 dimesylate; N-(2-((1-(4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide dimethanesulfonate
          CAS Number
          887401-93-6
          Molecular Formula
          C28H39F3N4O10S2
          Molecular Weight
          712.76
          Appearance
          A crystalline solid
          Purity
          98.00%
          Solubility
          Soluble in DMSO
          Storage
          Store at -20°C
          SMILES
          COC1=NC=C(C2(O)CCC(N3CCC(NC(CNC(C4=CC(C(F)(F)F)=CC=C4)=O)=O)C3)CC2)C=C1.CS(=O)(O)=O.CS(=O)(O)=O

          * For Research Use Only

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