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Overview
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Background
Interleukin-7 (IL-7) is a potent lymphoid cell growth factor produced by bone marrow and thymic stromal cells, spleen cells and keratinocytes. IL7 stimulates the proliferation of Pre-B, Pro-B and early T cells. IL-7 can co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Also, IL-7 stimulates the maturation of megakaryocytes and the proliferation and differentiation of NK cells.
The human IL-7 cDNA encodes a 177 aa protein with a 25 aa signal sequence. Human and murine IL-7 is cross-species reactive. Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.
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- Properties
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Overview