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Overview
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Background
After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways .
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