Name: IDR 1002
Price: Inquiry

- Overview
  - Innate defence regulator peptide.
    IDR 1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties which was identified from a library of bactenecin derivatives. IDR 1002 is protective against the Gram-negative bacterial pathogen Escherichia coli with chemokine induction by IDR 1002 being mediated through a Gi-coupled receptor and the PI3K, NF-kappaB, and MAPK signalling pathways. IDR 1002 suppresses in vitro inflammatory responses in murine monocyte/macrophage cells challenged with TLR4 and TLR2 agonists, and reduces airway hyperresponsiveness and inflammation in a house dust mite challenged model of airway inflammation.
    
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- Properties
  - Categories
    
    Antimicrobial Peptides
    
    Alternative Name
    
    Innate defense regulator peptide 1002
    
    Molecular Formula
    
    C79H130N26O13
    
    Molecular Weight
    
    1652.06
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Val-Gln-Arg-Trp-Leu-Ile-Val-Trp-Arg-Ile-Arg-Lys-NH2,VQRWLIVWRIRK-NH2
    Modification: C terminal amide
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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