Iberiotoxin

- Overview
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    Background
    
    Iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion Mesobuthus tamulus and was shown to selectively block large conductance Ca2+-activated K+ channels(BKCa) in smooth muscle cells.
    In single channel recordings, iberiotoxin can reversibly block outward currents mediated by BKCa in excised membrane patches from bovine aortic smooth muscle with an IC50 value of 250 pM. It is also a noncompetitive, partial inhibitor of charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki = 250 pM).
    
    Reference:
    [1]. Galvez A, Gimenez-Gallego G, Reuben J P, et al. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. The Journal of Biological Chemisty, 1990, 265(19): 11083-11090.
- Properties
  - Categories
    
    blocker of the big conductance Ca2+-activated K+ channel
    
    CAS Number
    
    129203-60-7
    
    Molecular Formula
    
    C179H274N50O55S7
    
    Molecular Weight
    
    4230.85
    
    Appearance
    
    A white to off-white solid
    
    Solubility
    
    Soluble in H2O
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    CC(CC1/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N\C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\2)CCCNC(N)=N)CSSCC2/C(O)=N/C(/C(O)=N/C(C(O)=O)CCC(O)=N)CC3=CC=C(O)C=C3)CCCCN)CCCCN)CCSC)CSSCC(/N=C(O)/C(
    
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