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Overview
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Background
Hypoxanthine is a natural purine derivative, with potential to be used as a free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury via oxygen radical production, and is thus involved in the pathogenesis of many diseases. Hypoxanthine also modulates a variety of other processes because it can react with benzodiazepine receptors and inhibit phosphodiesterase in the brain. Hypoxanthine has been reported to be used as an indicator of hypoxia.
1. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150.
2. Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.
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