Hydroxychloroquine Sulfate

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Hydroxychloroquine Sulfate is a synthetic quinine derivative commonly used as an antimalarial drug [1]. It is also useful in managing systemic lupus erythematosus, rheumatoid arthritis, and other diseases. Also acts as an inhibitor of autophagy and toll-like receptor 7/9(TLR7/9) [1-3].
    Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands [4].
    Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling [4].
    
    [1] Ben-Zvi I, Kivity S, Langevitz P, et al. Hydroxychloroquine: From Malaria to Autoimmunity. Clin. Rev. Allergy Immunol, 2012, 42 (2): 145-153.
    [2] Yildirim-Toruner C, Diamond B. Current and novel therapeutics in the treatment of systemic lupus erythematosus. Journal of Allergy and Clinical Immunology, 2011, 127 (2): 303-312.
    [3] Swierkot J, and Szechinski J. Methotrexate in rheumatoid arthritis. Pharmacol. Rep, 2006, 58 (4): 473-492.
    [4] Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol, 2014, 85 (3): 429-40.
- Properties
  - Alternative Name
    
    2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol; sulfuric acid
    
    CAS Number
    
    747-36-4
    
    Molecular Formula
    
    C18H28ClN3O5S
    
    Molecular Weight
    
    433.95
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥17.6 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Renjie Dou, Jinjun Qian, et al. "Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma." Cell Death Dis. 2021 Feb 24;12(2):206. PMID:33627630
    2. Zhuo Sun, Yidan Cao, et al. "Antiangiogenic effect of arsenic trioxide in HUVECs by FoxO3a‐regulated autophagy." J Biochem Mol Toxicol. 2021 Feb 16;e22728. PMID:33592126

Hydroxychloroquine Sulfate

Background

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