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Target Information
Target NameVon Willebrand Factor; Vwf Cleaved Into - Von Willebrand Antigen 2; Von Willebrand Antigen IiDatabase LinksVWF_HUMAN ; Reactome: R-HSA-114608 ; Gene ID: 7450About TargetTissue Specificity: Plasma.
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
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