Human UBE2C (Ubiquitin Conjugating Enzyme E2C) CLIA Kit

Ubiquitin-Conjugating Enzyme E2 C; (E3-Independent E2 Ubiquitin-Conjugating Enzyme C; E2 Ubiquitin-Conjugating Enzyme C; Ubch10; Ubiquitin Carrier Protein C; Ubiquitin-Protein Ligase C

UBE2C_HUMAN ; Reactome: R-HSA-141430 ; Gene ID: 11065

Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.