Human UCHL1 (Ubiquitin Carboxyl Terminal Hydrolase L1) CLIA Kit

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1; Uch-L1; Neuron Cytoplasmic Protein 9.5; Pgp 9.5; Pgp9.5; Ubiquitin Thioesterase L1

UCHL1_HUMAN ; Reactome: R-HSA-5689603 ; Gene ID: 7345

Tissue Specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.