Human TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) ELISA Kit

Tumor Necrosis Factor Receptor Superfamily Member 1a; Tumor Necrosis Factor Receptor 1; Tnf-R1; Tumor Necrosis Factor Receptor Type I; Tnf-Ri; Tnfr-I; P55; P60; Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1; Tbpi

TNR1A_HUMAN ; Reactome: R-HSA-5357786 ; Gene ID: 7132

Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.