Human TIMP-1 Kit

The Human TIMP-1 Kit provides assay-specific components for the quantitative determination of endogenous tissue inhibitor of metalloproteinase 1 (TIMP-1) in human serum, plasma, and cell supernatant. TIMP-1 is a glycoprotein that regulates the activation and inhibition of the matrix metalloproteinases (MMPs). The N-terminal site of TIMP-1 forms a non-covalent complex with the active site of the MMPs to inhibit active MMP-mediated proteolysis. TIMP-1 is widely present in many tissues and cell types. Overexpression of TIMP-1 correlates with aggressive pathogenesis of a variety of tumors. It has also been shown that total TIMP-1 plasma levels can be related to cardiovascular risk factors influencing cardiovascular remodeling via extracellular matrix degradation.

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Background

T-PLEX assay kits provide a rapid and convenient method for measuring the levels of biomarkers within a single, small-volume sample. The assays are available in both individual and multiplex formats. T-PLEX assay kits are research grade assays that are grouped into tissue culture, ultra-sensitive, whole cell lysate, serum/plasma, and base kits.

· Benefits: Analyzes protein levels from many sample types with a single assay. Improved analytical performance
· Format: Kits
· Multiplex: Compatible panels
· Sample compatibility: Secreted biomarker assays tested with serum, plasma, and cell culture supernatants; Intracellular assays tested with cell lysates