Human S100B (S100 Calcium Binding Protein B) ELISA Kit

Protein S100-B; S-100 Protein Beta Chain; S-100 Protein Subunit Beta; S100 Calcium-Binding Protein B

S100B_HUMAN ; Reactome: R-HSA-1251985 ; Gene ID: 6285

Tissue Specificity: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.