Human RUNX2 (Runt-Related Transcription Factor 2) ELISA Kit

Runt-Related Transcription Factor 2; Acute Myeloid Leukemia 3 Protein; Core-Binding Factor Subunit Alpha-1; Cbf-Alpha-1; Oncogene Aml-3; Osteoblast-Specific Transcription Factor 2; Osf-2; Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit; Pea2-Alpha A; Pebp2-Alpha A; Sl3-3 Enhancer Factor 1 Alpha A Subunit; Sl3/Akv Core-Binding Factor Alpha A Subunit

RUNX2_HUMAN ; Reactome: R-HSA-2032785 ; Gene ID: 860

Tissue Specificity: Specifically expressed in osteoblasts.

Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.