Human PSAP (Prosaposin) ELISA Kit

Prosaposin; Proactivator Polypeptide Cleaved Into - Saposin-A; Protein A - Saposin-B-Val - Saposin-B; Cerebroside Sulfate Activator; Csact; Dispersin; Sphingolipid Activator Protein 1; Sap-1; Sulfatide/Gm1 Activator - Saposin-C; A1 Activator; Co-Beta-Glucosidase; Glucosylceramidase Activator; Sphingolipid Activator Protein 2; Sap-2 - Saposin-D; Component C; Protein C

SAP_HUMAN ; Reactome: R-HSA-114608 ; Gene ID: 5660

Function: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.