Human PRG4 (Proteoglycan 4) ELISA Kit

Proteoglycan 4; Lubricin; Megakaryocyte-Stimulating Factor; Superficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part

PRG4_HUMAN ; Gene ID: 10216

Tissue Specificity: Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.

Function: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.