Human PON1 (Paraoxonase 1) CLIA Kit

Serum Paraoxonase/Arylesterase 1; Pon 1 ; Aromatic Esterase 1; A-Esterase 1; K-45; Serum Aryldialkylphosphatase 1

PON1_HUMAN ; Reactome: R-HSA-2142688 ; Gene ID: 5444

Tissue Specificity: Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.

Function: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.