Name: Human Platelet Derived Growth Factor-AA
Price: Inquiry

- Overview
  - Predicted MW: Dimer, 14.4/28.9 kDa (126/252 aa). Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-alpha, TGF-beta and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-alpha and PDGFR-beta .
    
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- Properties
  - Protein Name
    
    Platelet-derived growth factor subunit A, PDGF subunit A, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide
    
    Source
    
    Genetically modified E.coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Reducing and Non-Reducing SDS PAGE at >= 95%
    
    Formulation
    
    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
    Sterile water at 0.1 mg/mL
    
    Storage
    
    Store at -20°C
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    Activity
    
    Biological Activity was determined by 3T3 cell proliferation at = 2.0 x 10^4 units/mg (typical ED50 is < 25 ng/mL). Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
    
    More Information
    
    UniProt
    
    P04085
    
    Gene ID
    
    5154
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human Platelet Derived Growth Factor-AA

Human Platelet Derived Growth Factor-AA

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