Name: Human PD-L1 / B7-H1 Protein, Alpaca IgG2b Fc Tag
Price: Inquiry

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
- Properties
  - Host
    
    Human 293 cells (HEK293)
    
    Reactivity
    
    Human
    
    Immunogen
    
    Human PD-L1 Protein, Alpaca IgG2b Fc Tag is expressed from human 293 cells (HEK293). It contains AA Phe 19- Arg 238 (Accession # Q9NZQ7-1).
    
    Storage
    
    Store the lyophilized protein at -20℃ to -80℃ for long-term.
    Lyophilized from 0.22 μm filtered solution in PBS-based buffer, pH 7.4.
    After reconstitution, the protein solution is stable at -20℃ for 6month.
    Avoid repeated freeze/thaw cycles.
    
    Molecular Weight
    
    Calculated MW of 53.0 kDa. 65-95 kDa under reducing
    
    * For research use only.