Human PAPPA (Pregnancy Associated Plasma Protein A) ELISA Kit

Pappalysin-1; Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 Protease; Igf-Dependent Igfbp-4 Protease; Igfbp-4ase; Pregnancy-Associated Plasma Protein A; Papp-A

PAPP1_HUMAN ; Reactome: R-HSA-381426 ; Gene ID: 5069

Tissue Specificity: High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.

Function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.