Human Interleukin-33

Human Interleukin-33

Catalog Number:
P001418114ABE
Mfr. No.:
Abe32-12209
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      • Overview
        • Predicted MW: Monomer, 18.1 kDa (160 aa). Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-kB and MAPK signaling pathways. IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.

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      • Properties
        • Protein Name
          Interleukin-1 family member 11, Nuclear factor from high endothelial venules
          Source
          Genetically modified E.coli
          Type
          Recombinant Proteins
          Purification
          Reducing and Non-Reducing SDS PAGE at >= 95%
          Formulation
          Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
          Sterile water at 0.1 mg/mL
          Storage
          Store at -20°C
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
          Activity
          Biological Activity was determined by D10S cell proliferation at = 2.0 x 10^6 units/mg . Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.

          More Information

          UniProt
          Gene ID
          90865

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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