Name: Human Interleukin-21
Price: Inquiry

- Overview
  - Predicted MW: Monomer, 15.4 kDa (132 aa). Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
    
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- Properties
  - Protein Name
    
    Za11, Interleukin-21
    
    Source
    
    Genetically modified E.coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Reducing and Non-Reducing SDS PAGE at >= 95%
    
    Formulation
    
    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
    Sterile water at 0.1 mg/mL
    
    Storage
    
    Store at -20°C
    
    Endotoxin
    
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
    
    Activity
    
    Biological Activity was determined by ANBL-6 cell proliferation OR B9 cell proliferation at ED50 <= 2 ng/mL; >= 5.0 x 10^5 units/mg (typical ED50 is < 1 ng/mL) OR ED50 <= 50 ng/mL; >= 2.0 x 10^4 units/mg
    
    More Information
    
    UniProt
    
    Q9HBE4
    
    Gene ID
    
    59067
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human Interleukin-21

Human Interleukin-21

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