Human IL1R1 (Interleukin 1 Receptor Type I) CLIA Kit

Interleukin-1 Receptor Type 1; Il-1r-1; Il-1rt-1; Il-1rt1; Cd121 Antigen-Like Family Member A; Interleukin-1 Receptor Alpha; Il-1r-Alpha; Interleukin-1 Receptor Type I; P80; Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form; Mil-1r1; Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form; Sil-1r1; Sil-1ri

IL1R1_HUMAN ; Reactome: R-HSA-6783783 ; Gene ID: 3554

Tissue Specificity: Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.

Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.