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Human Growth and Differentiation Factor-11 (AF)

Human Growth and Differentiation Factor-11 (AF)

Catalog Number:
P001412015ABE
Mfr. No.:
Abe32-12086
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      • Overview

        • Predicted MW: Dimer, 12.5/24.9 kDa (109/218 aa). Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

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      • Properties
        • Protein Name
          Bone morphogenetic protein 11, BMP11
          Source
          Genetically modified E.coli
          Type
          Recombinant Proteins
          Purification
          Reducing and Non-Reducing SDS PAGE at >= 95%
          Formulation
          Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
          Sterile 10 mM HCl at 0.1 mg/mL
          Storage
          Store at -20°C
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
          Activity
          Biological Activity was determined by Alkaline phosphatase activity in ATDC5 cells at

          More Information

          UniProt
          O95390
          Gene ID
          10220

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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