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Overview
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Target Information
Target NameGlutamate Receptor Ionotropic - Nmda 1; Glun1; Glutamate Nmda Receptor Subunit Zeta-1; N-Methyl-D-Aspartate Receptor Subunit Nr1; Nmd-R1Database LinksNMDZ1_HUMAN ; Reactome: R-HSA-3928662 ; Gene ID: 2902About TargetFunction: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
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Overview