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Target Information
Target NameAppetite-Regulating Hormone; Growth Hormone Secretagogue; Growth Hormone-Releasing Peptide; Motilin-Related Peptide; Protein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28; Ghrelin - ObestatinDatabase LinksGHRL_HUMAN ; Reactome: R-HSA-375276 Q9UBU3-1 ; Gene ID: 51738About TargetTissue Specificity: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
Function: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
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