Human GHR (Growth Hormone Receptor) ELISA Kit

Growth Hormone Receptor; Gh Receptor; Somatotropin Receptor Cleaved Into - Growth Hormone-Binding Protein; Gh-Binding Protein; Ghbp; Serum-Binding Protein

GHR_HUMAN ; Reactome: R-HSA-1170546 ; Gene ID: 2690

Tissue Specificity: Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.

Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.