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Target Information
Target NameGrowth/Differentiation Factor 9; Gdf-9Database LinksGDF9_HUMAN ; Gene ID: 2661About TargetTissue Specificity: Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
Function: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
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