Human GDF15 (Growth Differentiation Factor 15) CLIA Kit

Growth/Differentiation Factor 15; Gdf-15; Macrophage Inhibitory Cytokine 1; Mic-1; Nsaid-Activated Gene 1 Protein; Nag-1; Nsaid-Regulated Gene 1 Protein; Nrg-1; Placental Tgf-Beta; Placental Bone Morphogenetic Protein; Prostate Differentiation Factor

GDF15_HUMAN ; Gene ID: 9518

Tissue Specificity: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Detected in plasma (at protein level).

Function: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling.