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Overview
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Predicted MW: Monomer, 19.4 kDa (177 aa). Fibroblast growth factor 4 (FGF-4) is a secreted growth factor that is predominantly expressed during bone morphogenesis and embryonic limb development. FGF-4 is an important growth regulator for stem cells, fibroblasts, and endothelial cells. FGF-4 contains a single N-linked glycosylation signal. In-vitro studies suggest that unglycosylated FGF-4 is cleaved into 13 kDa and 15 kDa truncated proteins that have greater biological activity than the wild type 19 kDa FGF-4 protein. Human FGF-4 shares high homology and is cross-reactive with mouse FGF-4.
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Overview