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Target Information
Target NameFibroblast Growth Factor 19; Fgf-19Database LinksUniprot ID: UBE2A_HUMAN ; Reactome: R-HSA-109704 ; Gene ID: 9965About TargetTissue Specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
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