Human FBLN5 (Fibulin 5) CLIA Kit

Fibulin-5; Fibl-5; Developmental Arteries And Neural Crest Egf-Like Protein; Dance; Urine P50 Protein; Up50

Uniprot ID: TTHY_HUMAN ; Reactome: R-HSA-1566948 ; Gene ID: 10516

Tissue Specificity: Expressed in skin fibroblasts (at protein level). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.

Function: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.