Human EFNA4 (Ephrin A4) CLIA Kit

Ephrin-A4; Eph-Related Receptor Tyrosine Kinase Ligand 4; Lerk-4

Uniprot ID: SPHK1_HUMAN ; Reactome: R-HSA-2682334 ; Gene ID: 1945

Tissue Specificity: Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.

Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.