Human EFNA3 (Ephrin A3) CLIA Kit

Ephrin-A3; Efl-2; Ehk1 Ligand; Ehk1-L; Eph-Related Receptor Tyrosine Kinase Ligand 3; Lerk-3

Uniprot ID: SPRL1_HUMAN ; Reactome: R-HSA-2682334 ; Gene ID: 1944

Tissue Specificity: Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes.

Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.