Human CYSLTR1 (Cysteinyl Leukotriene Receptor 1) CLIA Kit

Cysteinyl Leukotriene Receptor 1; Cysltr1; Cysteinyl Leukotriene D4 Receptor; Ltd4 Receptor; G-Protein Coupled Receptor Hg55; Hmtmf81

Uniprot ID: S10A1_HUMAN ; Reactome: R-HSA-391906 ; Gene ID: 10800

Tissue Specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.