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Overview
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Target Information
Target NameC-X-C Motif Chemokine 16; Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein; Sr-Psox; Small-Inducible Cytokine B16; Transmembrane Chemokine Cxcl16Database LinksUniprot ID: PTK6_HUMAN ; Reactome: R-HSA-380108 ; Gene ID: 58191About TargetTissue Specificity: Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Function: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
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Overview