Human CTSC (Cathepsin C) CLIA Kit

Dipeptidyl Peptidase 1; Cathepsin C; Cathepsin J; Dipeptidyl Peptidase I; Dpp-I; Dppi; Dipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain Chain; Dipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy Chain; Dipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light Chain; Dipeptidyl Peptidase I Light Chain

Uniprot ID: KGP1_HUMAN ; Reactome: R-HSA-204005 ; Gene ID: 1075

Tissue Specificity: Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.

Function: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.