Human CTSB (Cathepsin B) CLIA Kit

Cathepsin B; App Secretase; Apps; Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain

Uniprot ID: PRG4_HUMAN ; Reactome: R-HSA-1442490 ; Gene ID: 1508

Tissue Specificity: Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.

Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.