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Target Information
Target NameCyclin-Dependent Kinase Inhibitor 2a; Cyclin-Dependent Kinase 4 Inhibitor A; Cdk4i; Multiple Tumor Suppressor 1; Mts-1; P16-Ink4a; P16-Ink4; P16ink4aDatabase LinksUniprot ID: MUC7_HUMAN ; Reactome: R-HSA-2559580:::R-HSA-111471 ; Gene ID: 1029:::1029About TargetTissue Specificity: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
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