Human CASP3 (Caspase 3) ELISA Kit

Caspase-3; Casp-3; Apopain; Cysteine Protease Cpp32; Cpp-32; Protein Yama; Srebp Cleavage Activity 1; Sca-1 Cleaved Into - Caspase-3 Subunit P17 - Caspase-3 Subunit P12

Uniprot ID: LDHB_HUMAN ; Reactome: R-HSA-111459 ; Gene ID: 836

Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.