Human BMPR2 (Bone Morphogenetic Protein Receptor Ⅱ) ELISA Kit

Bone Morphogenetic Protein Receptor Type-2; Bmp Type-2 Receptor; Bmpr-2; Bone Morphogenetic Protein Receptor Type Ii; Bmp Type Ii Receptor; Bmpr-Ii

Uniprot ID: MBP_HUMAN ; Reactome: R-HSA-201451 ; Gene ID: 659

Tissue Specificity: Highly expressed in heart and liver.

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.