Human BECN1 (Beclin 1) ELISA Kit

Beclin-1; Coiled-Coil Myosin-Like Bcl2-Interacting Protein; Protein Gt197 Cleaved Into - Beclin-1-C 35 Kda - Beclin-1-C 37 Kda

Uniprot ID: GUC2B_HUMAN ; Reactome: R-HSA-1632852 ; Gene ID: 8678

Tissue Specificity: Ubiquitous.

Function: Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis.it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.