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Overview
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This APAF1 CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Please contact us at for specific academic pricing.
Target Information
Target NameApoptotic Protease-Activating Factor 1; Apaf-1Database LinksUniprot ID: FAS_HUMAN ; Reactome: R-HSA-111458 ; Gene ID: 317About TargetTissue Specificity: Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Function: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
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