Human APAF1 (Apoptosis Protease Activating Factor 1) CLIA Kit

Apoptotic Protease-Activating Factor 1; Apaf-1

Uniprot ID: FAS_HUMAN ; Reactome: R-HSA-111458 ; Gene ID: 317

Tissue Specificity: Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.

Function: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.