Human Alk-Smase (Alkaline Sphingomyelinase) CLIA Kit

Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 7; E-Npp 7; Npp-7; Alkaline Sphingomyelin Phosphodiesterase; Intestinal Alkaline Sphingomyelinase; Alk-Smase

Uniprot ID: EGLN_HUMAN ; Reactome: R-HSA-1660662 ; Gene ID: 339221

Tissue Specificity: Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.

Function: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity. May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen.