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Overview
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This ADRA1A CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
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Target Information
Target NameAlpha-1a Adrenergic Receptor; Alpha-1a Adrenoreceptor; Alpha-1a Adrenoceptor; Alpha-1c Adrenergic Receptor; Alpha-Adrenergic Receptor 1cDatabase LinksUniprot ID: CLTR2_HUMAN ; Reactome: R-HSA-390696 ; Gene ID: 148About TargetTissue Specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
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