Human ADAMTS5 (A Disintegrin And Metalloproteinase With Thrombospondin 5) ELISA Kit

A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5; Adam-Ts 5; Adam-Ts5; Adamts-5; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11; Adam-Ts 11; Adamts-11; Admp-2; Aggrecanase-2

Uniprot ID: DCX_HUMAN ; Reactome: R-HSA-1474228 ; Gene ID: 11096

Tissue Specificity: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.

Function: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.